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Published on: August 3, 2015
Protection by selenium against gentamicin-induced acute renal damage in the rat
Journal of Biochemistry
|March 1, 1984
Summary
Selenium supplementation significantly reduced kidney damage caused by gentamicin in rats. This protective effect was observed by measuring reduced enzyme excretion and improved renal function in selenium-treated animals.
Area of Science:
- Nephrology
- Biochemistry
- Toxicology
Background:
- Gentamicin is an antibiotic known to cause kidney damage.
- This damage is indicated by increased urinary excretion of specific kidney enzymes.
Purpose of the Study:
- To investigate the protective effect of selenium against gentamicin-induced nephrotoxicity.
- To assess changes in urinary enzyme excretion as biomarkers of renal damage.
Main Methods:
- Rats were pre-treated with selenium before gentamicin administration.
- Urinary volume, protein, and enzyme levels (alkaline phosphatase, acid phosphatase, beta-glucuronidase, muramidase, glutamate dehydrogenase) were measured.
- Renal function was evaluated in treated and control groups.
Main Results:
- Selenium pre-treatment markedly reduced the excretion of urine volume, proteins, and tested enzymes.
- Selenium-treated rats exhibited less renal adverse effects compared to gentamicin-only treated rats.
- Lysosomal enzymes (acid phosphatase, beta-glucuronidase, muramidase) showed the most significant response to selenium protection.
Conclusions:
- Selenium demonstrates a protective effect against gentamicin-induced nephrotoxicity in rats.
- Urinary enzyme profiles can serve as indicators for monitoring gentamicin-induced renal damage and selenium's protective efficacy.
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