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Related Experiment Videos

L-thyroxine absorption in patients with short bowel.

E Stone, L A Leiter, J R Lambert

    The Journal of Clinical Endocrinology and Metabolism
    |July 1, 1984
    PubMed
    Summary

    Thyroid hormone (L-T4) absorption occurs in the small intestine. Reduced absorption was observed in patients with shortened bowels, with no uptake in those with only a duodenum.

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    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Pharmacokinetics

    Background:

    • The precise location of oral thyroid hormone absorption in humans remains unidentified.
    • Understanding absorption sites is crucial for managing thyroid hormone replacement therapy.

    Purpose of the Study:

    • To investigate the absorption site of oral sodium-L-thyroxine (Na-L-T4) in humans.
    • To correlate thyroid hormone absorption with the length of the remaining small intestine.

    Main Methods:

    • Studied two healthy subjects and five patients with surgical bowel resections.
    • Administered oral [125I]Na-L-T4 tracer dose.
    • Measured serum radioactivity over time, with and without butanol extraction.

    Main Results:

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    • Normal subjects showed peak serum radioactivity at 2 hours post-ingestion.
    • Patients with shortened bowels exhibited significantly decreased [125I]Na-L-T4 absorption.
    • No absorption was detected in the patient with only a duodenum remaining.

    Conclusions:

    • Oral thyroid hormone absorption primarily occurs in the small intestine.
    • Significant bowel resection, particularly removal of the jejunum and ileum, impairs thyroid hormone absorption.
    • The duodenum alone is insufficient for significant thyroid hormone absorption.