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Related Experiment Videos

Microcystic adnexal carcinoma.

P H Cooper, S E Mills

    Journal of the American Academy of Dermatology
    |May 1, 1984
    PubMed
    Summary

    Microcystic adnexal carcinoma is a rare, locally aggressive facial cancer. This case highlights its extensive infiltration and recurrence, emphasizing the need for accurate diagnosis to distinguish it from other skin neoplasms.

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    Area of Science:

    • Dermatology
    • Pathology
    • Oncology

    Background:

    • Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm.
    • Accurate differentiation from other skin tumors is crucial due to its aggressive nature.

    Observation:

    • A middle-aged woman presented with MAC on the upper lip, nose, and later extensive recurrence involving the orbit and turbinates.
    • Microscopic examination revealed nests, strands, and keratin-filled cysts of atypical squamous cells infiltrating deep tissues and perineural spaces.

    Findings:

    • The tumor exhibited characteristic features of MAC, including squamous differentiation, dermal infiltration, and a sclerotic stroma.
    • Absence of epidermal connection and prominent ductular differentiation was noted, distinguishing it from other MAC variants.

    Implications:

    • This case underscores the locally aggressive behavior of MAC, with potential for extensive local invasion and recurrence.
    • Distinguishing MAC from common epidermal and adnexal neoplasms is vital for appropriate patient management and treatment planning.

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