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Related Experiment Videos

Relation between serum cathodic trypsinogen levels and exocrine pancreatic function.

A Andriulli, G Masoero, V Benitti

    Journal of Clinical Gastroenterology
    |June 1, 1984
    PubMed
    Summary
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    Serum circulating cathodic trypsinogen (CT) levels may indicate pancreatic acinar cell function. Immunoreactive trypsin measurement is more sensitive than enzymatic methods for assessing pancreatic secretory capacity in chronic pancreatitis.

    Area of Science:

    • Gastroenterology
    • Pancreatology
    • Biochemistry

    Background:

    • Exocrine pancreatic function assessment is crucial for diagnosing pancreatic diseases.
    • Circulating cathodic trypsinogen (CT) is a marker of pancreatic acinar cell activity.
    • Comparing different methods for measuring pancreatic function is essential for clinical utility.

    Purpose of the Study:

    • To evaluate the relationship between serum CT levels and exocrine pancreatic function.
    • To compare radioimmunological and enzymatic measurements of duodenal trypsin.
    • To assess diagnostic sensitivity of different markers in chronic pancreatitis (CP).

    Main Methods:

    • Exocrine pancreatic function was assessed in 34 controls and 32 CP patients.
    • Serum CT levels were measured.

    Related Experiment Videos

  • Duodenal trypsin was measured using both radioimmunological and enzymatic methods.
  • Bicarbonate output was also measured.

    • Main Results:

    • No correlation between serum CT and pancreatic secretion rate or duodenal bicarbonate in controls.
    • A good correlation was found between serum CT and duodenal trypsin when expressed as mean concentration and output in CP patients.
    • Serum CT correlated better with immunoreactive trypsin than enzymatic trypsin.
    • Low levels of function were detected in 29% (serum CT), 75% (bicarbonate), 63% (enzymatic trypsin), and 79% (immunoreactive trypsin) of CP patients.

    Conclusions:

    • Serum CT levels may reflect the functioning mass of pancreatic acinar cells.
    • Immunoreactive trypsin measurement is more sensitive and as accurate as bicarbonate output for assessing pancreatic secretory capacity in CP.
    • Enzymatic trypsin measurement is less sensitive than immunoreactive trypsin and bicarbonate output.