Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parathyroid hormone clearance in man.

S B Oldham, E J Finck, F R Singer

    Metabolism: Clinical and Experimental
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    The liver and kidneys significantly clear parathyroid hormone (PTH) in humans. PTH clearance by the kidney correlates with serum calcium levels, suggesting calcium modulates PTH removal.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A urine midmolecule osteocalcin assay shows higher discriminatory power than a serum midmolecule osteocalcin assay during short-term alendronate treatment of osteoporotic patients.

    Bone·2002
    Same author

    Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene.

    Human molecular genetics·2001
    Same author

    A clinical approach to diagnosis and management of Paget's disease of bone.

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2001
    Same author

    Long-term management and outcome of parathyroidectomy for sporadic primary multiple-gland disease.

    Archives of surgery (Chicago, Ill. : 1960)·2001
    Same author

    Bisphosphonate treatment inhibits the growth of prostate cancer cells.

    Cancer research·2001
    Same author

    The genetics of Paget's disease of the bone.

    The Journal of clinical endocrinology and metabolism·2001

    Area of Science:

    • Endocrinology
    • Nephrology
    • Metabolic Research

    Background:

    • Parathyroid hormone (PTH) is a key regulator of calcium and phosphate homeostasis.
    • Understanding the metabolic clearance pathways of PTH is crucial for comprehending endocrine regulation.
    • Previous studies suggested organ-specific roles, but a comprehensive analysis in humans was needed.

    Purpose of the Study:

    • To investigate the quantitative contribution of the kidney, liver, and peripheral tissues (bone/muscle) to the metabolic clearance of parathyroid hormone (PTH) in humans.
    • To determine if serum calcium levels influence the rate of PTH clearance.

    Main Methods:

    • Selective venous catheterization was performed on nine hyperparathyroid patients.
    • Blood samples were collected from the femoral artery and renal, hepatic, and femoral veins.

    Related Experiment Videos

  • Concentrations of intact immunoreactive parathyroid hormone (IPTH) were measured using radioimmunoassay and validated with gel filtration.

    • Main Results:

    • Significant arteriovenous (AV) differences in IPTH were observed across the liver (44%), kidney (34%), and leg (16%).
    • These AV differences were statistically significant (p < 0.005), indicating active uptake or degradation by these organs.
    • A positive correlation (r = 0.50, p < 0.05) was found between the kidney's AV difference in IPTH and serum calcium concentration.

    Conclusions:

    • The liver and kidney are major sites for PTH clearance in humans.
    • Bone and/or muscle also contribute to PTH clearance.
    • Serum calcium concentration may modulate the rate of PTH clearance by the kidney.