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Updated: Aug 13, 2026
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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Multinuclear NMR studies of naturally occurring nuclei
Summary
Nuclear magnetic resonance (NMR) spectroscopy allows in vivo biochemical measurements using surface coils. Phosphorus-31 (P-31) studies show diagnostic potential, despite challenges with carbon and hydrogen NMR.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Biochemistry
Background:
- In vivo nuclear magnetic resonance (NMR) spectroscopy enables biochemical process measurement.
- Surface coils are crucial for spatial localization in NMR studies.
- Previous research has focused on P-31, C-13, and H-1 nuclei for in vivo analysis.
Purpose of the Study:
- To review the capabilities of in vivo NMR spectroscopy for biochemical analysis.
- To highlight the utility of surface coils for localized NMR measurements.
- To discuss the application of P-31, C-13, and H-1 NMR in biological systems.
Main Methods:
- Utilizing surface coils for spatial localization in NMR experiments.
- Acquiring NMR spectra from localized regions in animal and human subjects.
- Analyzing P-31, C-13, and H-1 NMR data for biochemical insights.
Main Results:
- Intracellular pH and high-energy phosphate concentrations were measured in vivo.
- Abnormal marker compounds were detected in animal organs and human tissues.
- P-31 NMR studies demonstrated preclinical success with emerging diagnostic possibilities.
Conclusions:
- In vivo NMR spectroscopy with surface coils is a powerful tool for biochemical analysis.
- P-31 NMR shows significant promise for future clinical diagnostics.
- Technical challenges with C-13 and H-1 NMR require further investigation.
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