Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Absorption of phenobarbital from tablets and elixir.

M C Meyer, A B Straughn, G Raghow

    Journal of Pharmaceutical Sciences
    |April 1, 1984
    PubMed
    Summary

    This study compared phenobarbital tablets to an elixir, finding similar absorption. However, one tablet showed a significantly delayed peak concentration, linked to its dissolution rate.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Response to Comment on "Permanent human occupation of the central Tibetan Plateau in the early Holocene".

    Science (New York, N.Y.)·2017
    Same author

    Response to Comment on "Permanent human occupation of the central Tibetan Plateau in the early Holocene".

    Science (New York, N.Y.)·2017
    Same author

    Permanent human occupation of the central Tibetan Plateau in the early Holocene.

    Science (New York, N.Y.)·2017
    Same author

    RORγt expression in T<sub>regs</sub> promotes systemic lupus erythematosus via IL-17 secretion, alteration of T<sub>reg</sub> phenotype and suppression of Th2 responses.

    Clinical and experimental immunology·2016
    Same author

    Critical questions concerning the validity of the Bayer study report of "Differences in bioavailability between 60 mg of nifedipine osmotic push-pull systems after fasted and fed administration".

    International journal of clinical pharmacology and therapeutics·2010
    Same author

    Further notes on the leeches (Piscicolidae) living on fresh-water fishes of North America.

    Transactions of the American Microscopical Society·2010

    Area of Science:

    • Pharmacokinetics
    • Drug bioavailability
    • Pharmaceutical formulation

    Background:

    • Phenobarbital is a widely used anticonvulsant medication.
    • Assessing the bioavailability of different phenobarbital dosage forms is crucial for therapeutic equivalence.
    • Variability in tablet dissolution can impact drug absorption and efficacy.

    Purpose of the Study:

    • To determine the relative bioavailability of four phenobarbital tablet formulations compared to a reference elixir.
    • To investigate potential differences in pharmacokinetic profiles among phenobarbital dosage forms.

    Main Methods:

    • A three-way crossover study involving 24 healthy male volunteers.
    • Administration of four 100-mg phenobarbital tablets and one reference elixir at 30-day intervals.
    • Collection of plasma samples for 19 days post-dose to measure phenobarbital concentrations.

    Main Results:

    • Plasma phenobarbital concentrations and extent of absorption were similar across all dosage forms (within 10-20%).
    • The reference elixir showed the highest peak plasma concentration and shortest time to peak.
    • One tablet formulation exhibited a significantly longer time to peak concentration (8.6 h), correlating with in vitro dissolution.

    Conclusions:

    • All tested phenobarbital tablets demonstrated comparable bioavailability to the reference elixir.
    • In vitro dissolution rate is a significant factor influencing the in vivo absorption rate of phenobarbital tablets.
    • Formulation differences can lead to variations in the pharmacokinetic profiles of generic phenobarbital products.

    Related Experiment Videos