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[Ultrastructure of terminal myocardial arteries in chronic ischemic heart disease]

N K Furkalo, A S Gavrish

    Kardiologiia
    |April 1, 1984
    PubMed

    Insights

    This study reveals significant ultrastructural changes in coronary arteries and arterioles of patients with chronic coronary heart disease (CHD). These alterations impact vessel layers, affecting patency and tissue health.

    Area of Science:

    • Vascular Biology
    • Pathology
    • Cardiovascular Research

    Context:

    • Investigates terminal arteries and arterioles in patients undergoing aortocoronary bypass surgery.
    • Focuses on individuals with stenosing atherosclerosis and a history of chronic coronary heart disease (CHD).

    Purpose:

    • To elucidate the ultrastructural changes in coronary arteries and arterioles associated with chronic CHD.
    • To identify the cellular and structural modifications within the vessel walls.

    Summary:

    • Observed complex morphofunctional shifts affecting all layers of the vessel wall.
    • Identified key cellular players including endotheliocytes, smooth muscle cells, and stromal cells.
    • Noted fibroblastic proliferation contributing to vessel wall fibrosis.

    Impact:

    • Detected changes indicate impaired vessel patency and altered responsiveness.
    • Findings suggest significant effects on microcirculation and tissue trophicity.
    • Highlights the pathological remodeling in resistant coronary vessels.

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