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Related Experiment Videos

Activated coagulation time for rhesus monkeys (Macaca mulatta).

S P Schiffer, C S Gillett, D H Ringler

    Laboratory Animal Science
    |April 1, 1984
    PubMed
    Summary

    The activated coagulation time test offers a fast, accurate method for assessing blood clotting in rhesus monkeys. This reliable test is reproducible, cost-effective, and readily available.

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    Area of Science:

    • Veterinary Hematology
    • Primate Research
    • Coagulation Assays

    Background:

    • Accurate assessment of the intrinsic clotting system is crucial in non-human primate research.
    • Existing methods may be time-consuming or require specialized reagents.
    • Rhesus monkeys (Macaca mulatta) are a common model organism in biomedical studies.

    Purpose of the Study:

    • To evaluate the activated coagulation time (ACT) test for measuring intrinsic clotting in rhesus monkey whole blood.
    • To determine the feasibility and reliability of the ACT test in a primate model.

    Main Methods:

    • The activated coagulation time test was performed on whole blood samples from rhesus monkeys.
    • Data analysis included calculating mean values and ranges, and assessing variability.

    Main Results:

    • The ACT test provided a rapid and accurate measurement of the intrinsic clotting system.
    • The mean ACT for 60 normal rhesus monkeys was 96 seconds (range: 77-125 seconds).
    • No significant differences in ACT were observed based on sex, venipuncture site, or time of collection.

    Conclusions:

    • The activated coagulation time test is a practical, reproducible, and cost-effective method for assessing blood coagulation in rhesus monkeys.
    • Its commercial availability and lack of need for control samples further enhance its utility in primate research.

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