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A simple device for exteriorizing chronically implanted catheters in dogs.

J L Butterfield, G E Decker

    Laboratory Animal Science
    |April 1, 1984
    PubMed
    Summary
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    A novel polytetrafluoroethylene device effectively exteriorizes and protects chronic arterial and venous catheters in dogs. This maintenance-free implant showed excellent tissue tolerance and was well-tolerated in long-term studies.

    Area of Science:

    • Veterinary Surgery
    • Biomaterials Science
    • Medical Device Engineering

    Background:

    • Chronic implantation of arterial and venous catheters is essential for long-term monitoring and treatment in animal models.
    • Existing methods for catheter exteriorization and protection can be cumbersome and prone to complications.
    • Minimizing tissue reaction and ensuring long-term biocompatibility are critical for indwelling devices.

    Purpose of the Study:

    • To develop and evaluate a novel button-like device for exteriorizing and protecting chronically implanted arterial and venous catheters.
    • To assess the biocompatibility and long-term tolerance of the device in a canine model.
    • To identify the advantages of the new device compared to existing methods.

    Main Methods:

    • A round base and cap device made of polytetrafluoroethylene was designed.

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  • The device was subcutaneously implanted in conscious dogs for chronic catheter exteriorization.
  • Experiments were conducted for up to 9 months, with tolerance assessed in 200 dogs.

    • Main Results:

    • The polytetrafluoroethylene device was well-tolerated by 98% of the 200 dogs studied.
    • No significant tissue reactions were observed during experiments lasting up to 9 months.
    • The device demonstrated capacity for multiple catheter/wire outputs and required no protective harness.

    Conclusions:

    • The novel polytetrafluoroethylene device offers a safe and effective solution for exteriorizing and protecting chronic arterial and venous catheters in conscious dogs.
    • The device's maintenance-free nature, biocompatibility, and ease of use represent significant advantages for long-term animal studies.
    • This implantable device has the potential to improve the welfare and experimental outcomes in research involving chronic catheterization in animals.