Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The artificial heart in human subjects.

J Kolff, G M Deeb, N C Cavarocchi

    The Journal of Thoracic and Cardiovascular Surgery
    |June 1, 1984
    PubMed
    Summary

    The Utah J-7 pneumatic artificial heart was tested in brain-dead subjects before clinical use. This artificial heart successfully maintained physiological hemodynamics for up to 72 hours.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-acting formulations for the treatment of latent tuberculous infection: opportunities and challenges.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2018
    Same author

    Prototype Continuous Flow Ventricular Assist Device Supported on Magnetic Bearings.

    Artificial organs·2017
    Same author

    A Population Pharmacokinetic Model for Vancomycin in Adult Patients Receiving Extracorporeal Membrane Oxygenation Therapy.

    CPT: pharmacometrics & systems pharmacology·2016
    Same author

    Veno-venous extracorporeal membrane oxygenation using a double-lumen bi-caval cannula for severe respiratory failure post total artificial heart implantation.

    Perfusion·2014
    Same author

    A cost-reducing extracorporeal membrane oxygenation (ECMO) program model: a single institution experience.

    Perfusion·2014
    Same author

    Three European corn borer populations in New York based on sex pheromones and voltinism.

    Journal of chemical ecology·2013

    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Surgery
    • Medical Device Development

    Background:

    • Pre-clinical testing of the Utah J-7 pneumatic artificial heart is essential for its future use as a permanent cardiac substitute.
    • Five brain-dead human subjects were utilized to evaluate the artificial heart's functionality in a risk-free environment.

    Observation:

    • Three distinct surgical implantation techniques were employed across the five subjects.
    • The artificial heart's performance was assessed under conditions not feasible in living patients.

    Findings:

    • The implantable total artificial heart successfully maintained physiological hemodynamics in two subjects.
    • Sustained function was achieved for 41 hours in one subject and 72 hours in another.
    • Trials were electively terminated after the observation periods.

    Implications:

    • These findings provide critical data for the clinical preparation and potential success of the Utah J-7 artificial heart.
    • The study demonstrates the feasibility of using brain-dead subjects for advanced medical device testing.
    • Successful short-term hemodynamic support highlights the device's potential as a life-saving intervention.

    Related Experiment Videos