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Related Experiment Videos

Episodic angioedema associated with eosinophilia.

G J Gleich, A L Schroeter, J P Marcoux

    The New England Journal of Medicine
    |June 21, 1984
    PubMed
    Summary

    This study describes a rare syndrome of recurrent angioedema, urticaria, and fever. Eosinophil degranulation in the skin causes edema, with a generally benign clinical course.

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    Area of Science:

    • Immunology
    • Dermatology

    Background:

    • Recurrent angioedema, urticaria, and fever are rare symptoms.
    • Eosinophilic disorders can present with diverse clinical manifestations.

    Observation:

    • Four patients experienced recurrent attacks with significant weight gain and marked eosinophilia.
    • Histologic examination revealed eosinophil degranulation in the dermis, correlating with edema formation.

    Findings:

    • Glucocorticoid therapy effectively reduced fever, edema, and eosinophil counts.
    • No vital organ dysfunction or cardiac involvement was observed during long-term follow-up (2-17 years).

    Implications:

    • This syndrome may represent a distinct entity, potentially a variant of hypereosinophilic syndrome.
    • Understanding eosinophil's role in this condition aids in diagnosis and management.

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