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[Hypocomplementemic urticarial vasculitis with glomerulopathy and renal venulitis].

A Meyrier, P Français, P Lesavre

    Nephrologie
    |January 1, 1984
    PubMed
    Summary

    This study reports a rare case of chronic urticaria with angioedema and renal involvement, characterized by specific inflammatory markers and low complement levels. Treatment with corticosteroids effectively resolved the patient's symptoms and proteinuria.

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    Area of Science:

    • Immunology
    • Nephrology
    • Dermatology

    Background:

    • Atypical chronic urticaria can present with systemic manifestations beyond skin symptoms.
    • Hypocomplementemia, characterized by low complement levels, can indicate underlying autoimmune or inflammatory processes.

    Observation:

    • A 58-year-old woman presented with chronic urticaria, arthralgias, abdominal pain, and angioneurotic edema.
    • She exhibited signs of inflammation including leukoneutropenia, antileukocyte antibodies, and low complement levels (CH50, C1q, C4).
    • Skin biopsy revealed angiitis with a positive lupus band test, and renal biopsy showed mesangial deposits and inflammatory infiltrates.

    Findings:

    • Despite negative serologic tests for Systemic Lupus Erythematosus (SLE), the patient's presentation and biopsy results suggested an autoimmune-mediated vasculitis.

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  • The observed hypocomplementemia was not due to a functional C1 esterase deficiency.
  • Renal biopsy findings indicated immune complex deposition and inflammation.

    • Implications:

    • This case highlights McDuffie's angiitis as a differential diagnosis for chronic urticaria with systemic involvement.
    • It underscores the importance of comprehensive investigation, including complement studies and biopsies, in complex autoimmune presentations.
    • The findings contribute to understanding the mechanisms of hypocomplementemia in vasculitic syndromes.