Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A stochastic approach to tracer kinetics.

K Knesaurek, S Spaventi

    Nuklearmedizin. Nuclear Medicine
    |February 1, 1984
    PubMed
    Summary

    The single compartment well-mixed model (SCWMM) is inaccurate for short-lived isotopes. A new stochastic approach improves tracer behavior prediction by considering distribution, transport, and decay.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cerebral [<sup>18</sup> F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.

    Translational psychiatry·2016
    Same author

    Precise fusion of MRI and dual energy 111In WBC/99mTc HDP SPECT/CT in the diabetic foot using companion CT: an example of SPECT/MRI imaging.

    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2015
    Same author

    nm23-H1 expression and loss of heterozygosity in colon adenocarcinoma.

    Journal of clinical pathology·2004
    Same author

    Effective dose in sentinel lymph node imaging.

    The British journal of radiology·2004
    Same author

    New developments in PET instrumentation: quo vadis PET?

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2001
    Same author

    Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells.

    Journal of cancer research and clinical oncology·2001

    Area of Science:

    • Nuclear medicine
    • Pharmacokinetics
    • Biophysical modeling

    Background:

    • The single compartment well-mixed model (SCWMM) is widely used in nuclear medicine dynamic studies.
    • SCWMM's accuracy is limited to steady-state conditions with long-lived isotopes.
    • SCWMM fails to accurately predict the behavior of short-lived isotopes.

    Purpose of the Study:

    • To develop a more general stochastic approach for analyzing tracer behavior.
    • To accurately model the distribution and transport of both short- and long-lived isotopes.
    • To enable corrections for isotope decay in dynamic studies.

    Main Methods:

    • Development of a generalized stochastic model.
    • Incorporation of tracer distribution and transport dynamics.
    • Inclusion of decay correction mechanisms for short-lived isotopes.

    Main Results:

    • The proposed stochastic model overcomes SCWMM limitations for short-lived isotopes.
    • The model accurately predicts tracer behavior without assuming perfect mixing.
    • It provides a framework for analyzing complex tracer dynamics.

    Conclusions:

    • A generalized stochastic approach offers a more accurate and versatile tool for nuclear medicine dynamic studies.
    • This method enhances the understanding of tracer distribution and transport.
    • It is particularly valuable for studies involving short-lived isotopes and non-steady-state conditions.

    Related Experiment Videos