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Extracellular ascorbic acid increases in striatum following systemic amphetamine.

J D Salamone, L S Hamby, D B Neill

    Pharmacology, Biochemistry, and Behavior
    |April 1, 1984
    PubMed
    Summary
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    d-amphetamine sulfate administration in rats increased extracellular ascorbic acid in the anterior striatum for over two hours. This finding correlates with electrochemical measurements, suggesting amphetamine affects ascorbate levels.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Biochemistry

    Background:

    • The striatum plays a crucial role in motor control and reward.
    • Amphetamine is a psychostimulant known to affect neurotransmitter systems.
    • Ascorbic acid (vitamin C) is an important antioxidant with potential roles in neuronal function.

    Purpose of the Study:

    • To investigate the effect of d-amphetamine sulfate on extracellular ascorbic acid levels in the rat anterior striatum.
    • To correlate changes in ascorbic acid with electrochemical signals during amphetamine administration.

    Main Methods:

    • Push-pull perfusion technique was employed in freely moving rats.
    • High-performance liquid chromatography with electrochemical detection (HPLC-ECD) was used to measure ascorbic acid.

    Related Experiment Videos

  • Intrastriatal chronoamperometry was utilized for electrochemical measurements.

    • Main Results:

    • Administration of d-amphetamine sulfate (4 mg/kg) led to a significant increase in extracellular ascorbic acid.
    • The elevated ascorbic acid levels persisted for over two hours post-administration.
    • The time course of ascorbic acid increase mirrored the changes in oxidation current measured by chronoamperometry.

    Conclusions:

    • D-amphetamine sulfate significantly alters extracellular ascorbic acid levels in the anterior striatum.
    • These findings suggest a link between amphetamine's action and ascorbate dynamics in the brain.
    • Electrochemical methods provide a viable approach to monitor neurochemical changes induced by amphetamines.