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Summary
Two-stage surgical delay significantly improved skin-flap survival in pigs, unlike isoxsuprine, propranolol, or heparin. These drugs and single-stage delay did not enhance flap survival compared to controls.
Area of Science:
- Plastic Surgery
- Surgical Research
- Dermatology
Background:
- Previous studies suggested isoxsuprine, propranolol, and heparin improve skin-flap survival in animals with loose skin.
- The pig model offers a human-like skin circulation, making it suitable for evaluating these interventions.
Purpose of the Study:
- To assess the efficacy of isoxsuprine, propranolol, and heparin in enhancing skin-flap survival in pigs.
- To compare the effects of these drugs with surgical delay techniques (single-stage and two-stage).
Main Methods:
- Creation of 400 ventrally based skin flaps (proximal axial, distal random) in 40 pigs.
- Eight study groups: control, drug interventions (isoxsuprine, propranolol, heparin) with varying timing, single-stage surgical delay, and two-stage surgical delay.
Main Results:
- Two-stage surgical delay significantly increased skin-flap survival compared to control, drug, and single-stage delay groups (p < 0.001).
- Isoxsuprine, propranolol, heparin, and single-stage surgical delay did not significantly improve flap survival over controls.
Conclusions:
- Two-stage surgical delay is an effective method for improving skin-flap survival in a preclinical model.
- Pharmacological agents like isoxsuprine, propranolol, and heparin, as well as single-stage surgical delay, showed no significant benefit for flap survival in this study.