[Radioprotective effectiveness of gas hypoxic mixture GHM-10 in experiments on dogs]

In experiments on 128 dogs (males and females) weighing 7-24 kg it was demonstrated that inhalation of gas hypoxic mixture containing O2 (10%) and N2 (90%) decreased significantly the level of PO2 in radiosensitive tissues and exerted a radioprotective effect on the exposed animals (60Co, doses of 2.8, 3.5-3.8 and 4.2 Gy, DMF = 1.3). At a dose of 8 Gy the average life of animals increased from 6.2 +/- 0.8 days (control) up to 9.3 +/- 1.1 days after the application of GHM -10.