Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The histamine inhalation provocation test and its reproducibility.

G P ten Velde, J Kreukniet

    Respiration; International Review of Thoracic Diseases
    |January 1, 1984
    PubMed
    Summary

    The histamine inhalation provocation test (HIP) for asthma assessment shows moderate reproducibility. Airway hyperreactivity in asthmatic patients correlates significantly with initial FEV1 values.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diagnostic yield of computed tomography and densitometric measurements of the lung in thoracoscopically-defined idiopathic spontaneous pneumothorax.

    Respiratory medicine·2001
    Same author

    Prospective study on quality of life before and after radical radiotherapy in non-small-cell lung cancer.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2001
    Same author

    Pretreatment quality of life of inoperable non-small cell lung cancer patients referred for primary radiotherapy.

    Acta oncologica (Stockholm, Sweden)·2001
    Same author

    Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis.

    Journal of neuro-oncology·2000
    Same author

    Phase III comparative study of high-dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-small-cell lung cancer.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2000
    Same author

    Rebreathing K(CO) and single breath K(CO) measured at the same mean alveolar volume reveal a physiological relationship between unequal diffusion and unequal ventilation in normal subjects.

    Respiration; international review of thoracic diseases·2000

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Asthma is characterized by airway hyperresponsiveness.
    • Accurate assessment of bronchial reactivity is crucial for asthma management.

    Purpose of the Study:

    • To evaluate the reproducibility of the histamine inhalation provocation test (HIP) in asthmatic patients.
    • To investigate the correlation between initial FEV1 and bronchial response to histamine.

    Main Methods:

    • Standardized histamine inhalation provocation tests were performed 4-5 times over 5 weeks in 21 asthmatic patients.
    • Increasing concentrations of histamine phosphate were used.
    • A positive test was defined by a ≥15% drop in initial FEV1.

    Main Results:

    • 57% of patients (12/21) demonstrated sufficient reproducibility of the HIP.
    • While the mean histamine concentration for a positive test showed little variability across the group, individual patient responses varied widely.
    • A highly significant correlation (p<0.0001) was found between initial FEV1 and bronchial response.

    Conclusions:

    • The histamine inhalation provocation test (HIP) may not always be reproducible within a short timeframe.
    • Airway hyperreactivity in asthma is significantly correlated with the initial FEV1.
    • Initial FEV1 may be an important factor to consider when interpreting HIP results.

    Related Experiment Videos