[Regional anticoagulant therapy after microvascular surgery with permanent intra-arterial administration of heparin]

Experiments on 32 dogs have shown that the greatest effect of medication on particular anatomical zone may be achieved by maximum approximation of the level of catheterization of the feeding artery to the zone. It may be achieved by the microsurgery technique. Permanent intraarterial administration of solutions of heparin in experiments and clinic is thought to provide a sufficient effect of the regional anticoagulating therapy, by creating a high concentration of the drug in the zone of microanastomosis with its low concentration in the general blood flow.