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Updated: Aug 25, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
[Effect of ribavirin on the reproduction of influenza B virus]
Abstract:
The influence of ribavirin on influenza B virus reproduction was studied at different experimental levels. Ribavirin was found to reduce significantly the production of hemagglutinin and accumulation of infectious influenza B/Lee/40 virus in MDCK cell culture. Synthesis of virus-specific polypeptides of influenza B/Hong Kong/5/72 virus was markedly reduced in its presence. Ribavirin in a dose of 100 mg/kg inhibited the infectious titre of influenza B/Lee/40 virus considerably and prevented the development of inflammatory reactions in pulmonary tissue of white mice.
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