Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neurotropic influenza type A viruses].

J Bonin, C Scholtissek

    Voprosy Virusologii
    |March 1, 1984
    PubMed
    Summary

    Influenza A virus neurovirulence in mice is linked to its gene constellation. Specific gene substitutions can alter or restore neurotropic properties, with viruses entering the brain via the trigeminal nerve.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Molecular catalysis of CO<sub>2</sub> reduction: recent advances and perspectives in electrochemical and light-driven processes with selected Fe, Ni and Co aza macrocyclic and polypyridine complexes.

    Chemical Society reviews·2020
    Same author

    Solvation dynamics of electron produced by two-photon ionization of liquid polyols. III. Glycerol.

    The journal of physical chemistry. A·2008
    Same author

    Solvation dynamics of electron produced by two-photon ionization of liquid polyols. II. Propanediols.

    The journal of physical chemistry. A·2007
    Same author

    Solvation dynamics of the electron produced by two-photon ionization of liquid polyols. 1. Ethylene glycol.

    The journal of physical chemistry. A·2006
    Same author

    Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia.

    Proceedings of the National Academy of Sciences of the United States of America·2005
    Same author

    [Distribution of opisthorchiid liver flukes in red foxes (Vulpes vulpes) in western Brandenburg].

    Berliner und Munchener tierarztliche Wochenschrift·2001

    Area of Science:

    • Virology
    • Neuroscience
    • Genetics

    Context:

    • Influenza A/turkey/England/63 exhibits neurotropic properties in mice.
    • Hemagglutinin gene substitution impacts viral neurovirulence.
    • Reassortment of influenza virus genes can generate novel pathogenic strains.

    Purpose:

    • To investigate the genetic basis of influenza A virus neurovirulence in mice.
    • To determine the role of specific genes, such as hemagglutinin, in viral neurotropism.
    • To establish a correlation between the gene constellation and neurovirulence.

    Summary:

    • Influenza A/turkey/England/63 is neurotropic for mice.
    • Substitution of its hemagglutinin gene with that of A/FPV/Rostok/34 abolishes neurovirulence.
    • Hybridization of nonpathogenic strains yielded highly virulent recombinants.
    • A correlation between gene constellation and mouse neurovirulence was established.
    • Neurovirulent viruses utilize the trigeminal nerve to access the brain after intranasal administration, bypassing the bloodstream.

    Impact:

    • Identifies specific genetic factors influencing influenza A virus neurovirulence.
    • Provides insights into viral pathogenesis and host-pathogen interactions.
    • Contributes to understanding mechanisms of viral entry into the central nervous system.

    Related Experiment Videos