[Evaluation of activity and the electron microscope picture in Paget's disease]

Thirteen patients with Paget's disease followed-up for prolonged periods of time were subjected to a series of biological tests and to studies of radionuclides incorporation into skeletal tissues. Bone alkaline phosphatase showed an osteoblastic activity, and tartarate -resistant acid phosphatases an osteoclastic function. Hydroxyproline in urine corresponded to the osteoclastic destruction. The X-ray pattern did not agree necessarily with the local metabolic bone activity of phosphates ( 99mTechnetium pyrophosphate), or of glycoproteins (85Sr). The use of scanning was recommended for studies of local activity and to correlate the results obtained with the clinical and biochemical syndromology . The electronoptic pattern was similar to that observed in inclusions of the paramyxovirus or papova virus. The problems associated with the differential diagnosis were discussed.