[Interactions of oral anti-diabetic agents and non-steroid anti-rheumatic agents]

Due to the relative increase of age-diabetes and to the different forms of rheumatic diseases, long-term medicament therapy and the question of possible interactions between oral antidiabetic drugs ( OAD ) and nonsteroidal anti-inflammatory drugs (NSAID) become more important. Unfortunately there exist studies on most of the well-known NSAID, but carried out on different conditions. The present study is intended to summarize the results at hand and to evaluate them in a certain sense. From almost all the NSAID, except from the salicylates and those connected with, as well as the pyrazolones, one may say, based on published data and long-term experience, that interactions with the OAD in use nowadays are not to be expected unless without clinical relevance.