Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic hemodynamics in nephrotoxic acute renal failure.

T W Kurtz, C H Hsu

    Nephron
    |January 1, 1978
    PubMed
    Summary

    Mercuric chloride (HgCl2) induces acute renal failure, decreasing cardiac output and renal blood flow. Plasma volume expansion can normalize these hemodynamic parameters, suggesting factors beyond renal vasoconstriction contribute to HgCl2-induced kidney injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Author Correction: Fermionic order by disorder in a van der Waals antiferromagnet.

    Scientific reports·2023
    Same author

    Comprehensive Lifestyle Improvement Program for Prostate Cancer (CLIPP) is associated with improvement in weight and components of metabolic syndrome in men exposed to androgen deprivation therapy for prostate cancer.

    Prostate cancer and prostatic diseases·2021
    Same author

    Protocol for a feasibility and early efficacy study of the Comprehensive Lifestyle Improvement Program for Prostate Cancer-2 (CLIPP2).

    Contemporary clinical trials communications·2021
    Same author

    Fermionic order by disorder in a van der Waals antiferromagnet.

    Scientific reports·2020
    Same author

    Distribution of Antimicrobial Resistance Genes Across Salmonella enterica Isolates from Animal and Nonanimal Foods.

    Journal of food protection·2020
    Same author

    Complete Genome Sequences of Two Avilamycin-Resistant Enterococcus faecium Strains Isolated from Chicken in the United States.

    Microbiology resource announcements·2019

    Area of Science:

    • Nephrology
    • Cardiovascular Physiology
    • Toxicology

    Background:

    • Acute kidney injury (AKI) is a critical condition with significant morbidity and mortality.
    • Mercuric chloride (HgCl2) is a nephrotoxin commonly used to induce experimental AKI.
    • Understanding the hemodynamic alterations in AKI is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the effects of HgCl2-induced AKI on cardiac output (CO) and renal blood flow (RBF) in a rat model.
    • To assess the role of plasma volume expansion in mitigating these hemodynamic changes.
    • To explore the underlying mechanisms contributing to renal ischemia in HgCl2-induced AKI.

    Main Methods:

    • Simultaneous measurement of CO and RBF using the microsphere method in awake rats.
    • Induction of AKI via a single intravenous injection of HgCl2 (4.7 mg/kg body weight).
    • Assessment of hemodynamic parameters (CO, RBF, renal vascular resistance, total peripheral resistance) at 3, 6, and 24 hours post-HgCl2 administration.
    • Evaluation of plasma volume expansion effects through intravenous plasma infusion.

    Main Results:

    • HgCl2 injection led to significant reductions in CO (to 77%) and RBF (to 72%) by 3 hours, accompanied by increased renal and total peripheral resistance.
    • These hemodynamic derangements persisted at 6 hours post-HgCl2.
    • Plasma volume expansion successfully normalized CO, RBF, and resistance parameters at 3 hours.
    • Despite elevated blood urea nitrogen at 24 hours, all hemodynamic parameters returned to control levels, with a significant increase in plasma volume observed.

    Conclusions:

    • HgCl2-induced AKI causes transient but significant reductions in cardiac output and renal blood flow.
    • Plasma volume expansion is effective in restoring normal hemodynamics during the acute phase of HgCl2-induced AKI.
    • The findings suggest that factors beyond simple renal vasoconstriction contribute to the renal ischemia observed in HgCl2-induced AKI, highlighting the complex pathophysiology of this condition.

    Related Experiment Videos