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Related Experiment Videos

Urinary free cortisol during pregnancy.

A L Mikkelsen, C Felding, H Hasselbalch

    Acta Obstetricia Et Gynecologica Scandinavica
    |January 1, 1984
    PubMed
    Summary
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    Urinary free cortisol levels in pregnancy show significant daily fluctuations, with no change between early and late stages. These variations are independent of estrogen levels or kidney function.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Clinical Chemistry

    Background:

    • Adrenocortical function undergoes significant physiological changes during pregnancy.
    • Understanding cortisol dynamics is crucial for assessing maternal and fetal well-being.

    Purpose of the Study:

    • To evaluate adrenocortical function in normal early and late pregnancy.
    • To assess the variability of urinary free cortisol excretion throughout gestation.

    Main Methods:

    • Measurement of urinary free cortisol on three consecutive days.
    • Analysis of samples from women in early and late normal pregnancies.
    • Correlation analysis with estrogen levels and creatinine clearance.

    Main Results:

    Related Experiment Videos

    • Significant intra-individual variation in daily urinary free cortisol excretion was observed.
    • This pattern of variation remained consistent between early and late pregnancy.
    • No correlation was found between urinary free cortisol, estrogen levels, and creatinine clearance.

    Conclusions:

    • Urinary free cortisol excretion exhibits marked daily variability in normal pregnancy.
    • This variability does not significantly change between early and late gestation.
    • Adrenocortical function, as assessed by urinary free cortisol, is not directly correlated with estrogen levels or renal function during pregnancy.