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Endothelial changes of hypertensive rat mesenteric arteries
Acta Pathologica Japonica
|January 1, 1984
Summary
Hypertensive arterial lesions in rats involve endothelial cell degeneration, necrosis, and denudation. These changes, along with open cell junctions, facilitate plasma insudation, contributing to lesion development.
Area of Science:
- Vascular Biology
- Pathology
Background:
- Hypertension is a major risk factor for cardiovascular disease.
- Understanding the early cellular mechanisms of arterial lesion formation is crucial.
Purpose of the Study:
- To investigate the early cellular and ultrastructural changes in mesenteric arteries of hypertensive rats.
- To elucidate the role of endothelial cells and junctions in hypertensive arterial lesion genesis.
Main Methods:
- Light microscopy
- Scanning electron microscopy
- Transmission electron microscopy
- Observation of mesenteric arteries from hypertensive rats with renal artery constriction.
Main Results:
- Early lesions showed leukocyte adhesion to the endothelium.
- Endothelial cells exhibited degeneration, coagulation necrosis, and denudation.
- Opened endothelial cell junctions and enlarged intercellular spaces were observed, with leukocyte and platelet adhesion.
- Fibrinoid substance deposition correlated with opened junctions and endothelial denudation.
Conclusions:
- Endothelial cell degeneration, necrosis, and denudation are key events in hypertensive arterial lesion development.
- Opened endothelial cell junctions facilitate blood plasma insudation, contributing to lesion formation.
- These cellular changes play significant roles in the pathogenesis of hypertensive rat arterial lesions.