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Antithrombins and coronary artery disease
American Journal of Clinical Pathology
|June 1, 1984
Summary
Plasma antithrombin-III levels do not appear significant for diagnosing coronary artery disease. This study found most patients with documented disease had normal levels, with no correlation to severity.
Area of Science:
- Cardiovascular Medicine
- Hematology
Background:
- The role of antithrombin-III in atherogenesis and myocardial infarction is debated.
- Previous studies report conflicting findings on antithrombin-III levels in coronary artery disease (CAD).
Purpose of the Study:
- To investigate the association between plasma antithrombin-III levels and the presence/severity of coronary artery disease.
Main Methods:
- Antithrombin-III levels were measured in 86 patients undergoing coronary angiography.
- Coronary artery disease severity and site of involvement were assessed via angiography.
Main Results:
- The majority of patients with angiographically confirmed CAD had normal antithrombin-III levels.
- No significant correlation was found between antithrombin-III levels and the extent or location of coronary artery disease.
Conclusions:
- Plasma antithrombin-III levels are not a significant indicator for diagnosing coronary artery disease.
- Antithrombin-III measurements lack clinical utility in assessing the presence, absence, or severity of CAD.