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Related Experiment Videos

A fluorescent spot test for coagulation factor XIII.

M Coggan, P G Board

    Analytical Biochemistry
    |March 1, 1984
    PubMed
    Summary
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    A novel fluorescent spot test using monodansylcadaverine enables rapid detection of coagulation factor XIII (FXIII). This method is valuable for monitoring purification and diagnosing FXIII deficiency in plasma samples.

    Area of Science:

    • Biochemistry
    • Clinical Diagnostics

    Background:

    • Coagulation factor XIII (FXIII) is crucial for hemostasis.
    • Accurate and rapid detection methods for FXIII are essential for clinical diagnostics and research.

    Purpose of the Study:

    • To introduce a new, rapid detection method for coagulation factor XIII.
    • To validate the utility of this method in purification procedures and diagnosing FXIII deficiency.

    Main Methods:

    • Development of a fluorescent spot test utilizing the amine monodansylcadaverine.
    • Application of the test for sample screening during protein purification.
    • Use of the test for diagnosing factor XIII deficiency in plasma.

    Main Results:

    • The described method allows for rapid detection of coagulation factor XIII.

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  • The technique is suitable for high-throughput screening of samples during purification.
  • The test effectively diagnoses factor XIII deficiency in plasma samples.

    • Conclusions:

    • A novel, rapid, and efficient fluorescent spot test for coagulation factor XIII has been developed.
    • This method serves as a valuable tool for both research purification processes and clinical diagnosis of FXIII deficiency.