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Effects of halothane anesthesia on equine liver function.

L R Engelking, N H Dodman, G Hartman

    American Journal of Veterinary Research
    |April 1, 1984
    PubMed
    Summary
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    Halothane anesthesia significantly increased bilirubin excretion and concentration in ponies, while reducing bile acid levels. Liver function remained stable, suggesting a complex response to anesthesia.

    Area of Science:

    • Veterinary Medicine
    • Anesthesiology
    • Hepatology

    Background:

    • Biliary fistulas (T tubes) were surgically created in ponies to study liver function.
    • Enterohepatic circulation was maintained intact throughout the studies.

    Purpose of the Study:

    • To investigate the effects of halothane anesthesia on liver function and biliary excretion in ponies.
    • To determine how halothane impacts bilirubin and bile acid metabolism during a 2-hour anesthesia period.

    Main Methods:

    • Four studies were conducted on two ponies 2-6 months post-surgery.
    • Intravenous bile acid infusion maintained steady-state bile flow, bilirubin, and bile acid excretion.
    • Bile and plasma parameters were analyzed during and before halothane anesthesia.

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    Main Results:

    • Halothane anesthesia increased bilirubin excretion by 138% and biliary bilirubin concentration by 60%.
    • Bile acid concentration decreased by 46% and excretion by 27% during anesthesia.
    • Packed cell volume (PCV) increased by 43%, while plasma aspartate transaminase remained unchanged.

    Conclusions:

    • Halothane anesthesia in ponies leads to increased conjugated bilirubin excretion, likely due to enhanced hepatic clearance and production.
    • The anesthetic did not adversely affect transferase-conjugating enzyme activity despite increased bilirubin load.
    • Changes suggest a complex hepatic response to halothane, involving altered bilirubin and bile acid handling.