Effects of various compounds on the accumulation of macrophages in mice

The effects of different anti-inflammatory and anti-rheumatic compounds on the accumulation of macrophages in mice have been investigated. Glass coverslips were inserted subcutaneously and the cellular accumulation evaluated by measuring the surface covered by cells or the cellular potassium. Among the non-steroidal anti-inflammatory compounds tested, only niflumic acid and BW 755C were found active in this assay. Hydrocortisone, chloroquine and cyclophosphamide inhibited partially the migration of cells. Na- aurothiopropanol sulfonate, levamisole and methotrexate were inactive. MK 447 and d-penicillamine increased the accumulation of macrophages. The activity of the different substances is discussed in terms of their modes of action.