Hypothalamic self-stimulation: the role of dopamine and possible relations to neocortical slow wave activity

Reserpine abolishes self-stimulation in rats but the behavior can be restored temporarily by treatment with D-amphetamine or L-DOPA. Apomorphine does not restore self-stimulation even though it restores spontaneous motor activity in reserpinized rats. The data indicate that dopamine plays a role in reinforcement as well as in motor function. The ability of D-amphetamine to restore self-stimulation in reserpinized rats is eliminated by concurrent treatment with atropine or scopolamine. This effect may be related to the presence of continuous large amplitude slow wave activity in the neocortex under these conditions.