Increased concentrations of immunoreactive leukotrienes in cutaneous lesions of eosinophilic cellulitis

A case of eosinophilic cellulitis is described. Tests of eosinophil function were normal. Radioimmunoassay identification of inflammatory mediators showed greatly increased concentrations of leukotrienes LTC4/D4 (components of slow-reacting substance of anaphylaxis) in the affected skin. These mediators may play a causal role in the inflammation seen with eosinophilic cellulitis.