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Abstract:
Spinally-projecting A5 noradrenergic neurons were recorded in urethane-anesthetized rats. All A5 neurons sampled were inhibited by raising the mean arterial blood pressure (mBP) in the 110-160 mm Hg range. Similar elevations of mBP in baroreceptor-denervated rats were without effect. Clonidine inhibited A5 neurons and enhanced the inhibitory effect of increasing peripheral blood pressure.