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Developmental changes in environmentally induced analgesia.

R J Hamm, J S Knisely

    Brain Research
    |May 1, 1984
    PubMed
    Summary
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    Young rats show less pain relief from shock due to developing opioid systems. Naloxone

    Area of Science:

    • Neuroscience
    • Pain Research
    • Developmental Biology

    Background:

    • Inescapable shock induces opioid-mediated analgesia.
    • Opioid receptor development occurs primarily from birth to adulthood.

    Purpose of the Study:

    • To investigate the link between opioid receptor maturation and the function of the endogenous opioid pain-inhibitory system activated by shock.
    • To examine age-related differences in shock-induced analgesia and naloxone's effects.

    Main Methods:

    • Exposure of rats (10-day-old, 28-day-old, 5-7-month-old) to 90 seconds of front-paw shock (1.6 mA).
    • Administration of naloxone to assess its effect on shock-induced analgesia across age groups.

    Main Results:

    • 10-day-old rats exhibited significantly lower shock-induced analgesia compared to older rats.

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  • Naloxone increased analgesia in 10-day-old rats, fully blocked it in 28-day-old rats, and only partially reduced it in 5-7-month-old rats.
  • The partial blockade by naloxone in adult rats suggests the involvement of a non-opioid analgesia system.

    • Conclusions:

    • Shock-induced analgesia and opioid receptor development are parallel processes.
    • A non-opioid pain-inhibitory system appears to develop later than the opioid system, emerging after 28 days of age.