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Cimetidine-induced fever.

K Landolfo, D E Low, A G Rogers

Canadian Medical Association Journal

|June 15, 1984

Summary

This summary is machine-generated.

Cimetidine rarely causes drug-induced fever. In a patient, fever was the only symptom of a cimetidine adverse reaction, confirmed by drug challenge, even without hypersensitivity.

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Area of Science:

Pharmacology
Clinical Medicine
Immunology

Background:

Drug-induced fever is an uncommon adverse drug reaction.
Cimetidine is a histamine H2 receptor antagonist used to treat various gastrointestinal conditions.

Observation:

A patient presented with fever as the sole clinical manifestation of an adverse drug reaction.
In vitro lymphocyte studies did not indicate a hypersensitivity reaction to cimetidine.

Findings:

The patient's fever was attributed to cimetidine, a rare cause of drug-induced fever.
Re-challenge with cimetidine confirmed it as the causative agent for the fever.
The absence of in vitro hypersensitivity markers suggests a non-immunological or atypical immune mechanism.

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Implications:

This case highlights that drug-induced fever can occur with cimetidine even without typical hypersensitivity markers.
Clinicians should consider cimetidine as a potential cause of unexplained fever, even in the absence of other allergic symptoms.
Further investigation into the mechanisms of cimetidine-induced fever may be warranted.