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Updated: Aug 2, 2026

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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Maximal treadmill tests five years apart in asymptomatic men aged 45-72 years
Summary
This study found that healthy older men experience gradual declines in exercise capacity and increased frequency of exercise-induced ST depression and ventricular arrhythmias over five years. The clinical significance of these common findings in asymptomatic individuals remains unclear.
Area of Science:
- Cardiology
- Exercise Physiology
- Gerontology
Background:
- Cardiovascular health and exercise capacity naturally decline with age.
- Understanding age-related changes in cardiac function during exercise is crucial for assessing cardiovascular risk in older men.
Purpose of the Study:
- To evaluate longitudinal changes in exercise performance and exercise-induced electrocardiographic (ECG) abnormalities in asymptomatic older men.
- To assess the prevalence and changes in ST-segment depression and ventricular arrhythmias during maximal treadmill testing over a five-year period.
Main Methods:
- Two maximal treadmill tests (Bruce protocol) were administered to 169 asymptomatic male volunteers (aged 45-72 years) five years apart.
- Measurements included treadmill endurance time, maximal heart rate, and exercise-induced ST-segment changes and ventricular ectopic activity on ECG.
Main Results:
- Treadmill endurance time declined by 4-8 seconds/year, and maximal heart rate decreased by approximately 1 beat/min/year.
- Exercise-induced ST-segment depression increased from 26% at baseline to 38% at follow-up, with significant inter-test variability.
- Ventricular ectopic beats increased from 22% to 37%, with complex ventricular activity rising from 2% to 9%.
Conclusions:
- Asymptomatic older men exhibit a high frequency of exercise-induced ST depression and ventricular arrhythmias.
- These findings are common and fluctuate over time, suggesting that intervention may not always be necessary.
- Further research is needed to determine the clinical implications and appropriate management of these exercise-induced cardiac findings in this population.

