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Hepatic dysfunction in primary hypothyroidism.

J Tajiri, T Shimada, S Naomi

    Endocrinologia Japonica
    |February 1, 1984
    PubMed
    Summary
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    Hypothyroidism impacts liver function, with many patients showing abnormal liver enzymes and cholesterol. Thyroid hormone replacement therapy normalized these liver function abnormalities.

    Area of Science:

    • Endocrinology
    • Hepatology
    • Internal Medicine

    Background:

    • Primary hypothyroidism is a common endocrine disorder.
    • Thyroid hormones play a crucial role in regulating various metabolic processes, including liver function.
    • The relationship between thyroid hormone deficiency and hepatic dysfunction requires further elucidation.

    Observation:

    • This study investigated hepatic function in 27 patients with primary hypothyroidism.
    • Common abnormalities observed included hypergammaglobulinemia (71%), elevated glutamic oxaloacetic transaminase (GOT) (48%), high lactic dehydrogenase (LDH) (58%), hypercholesteremia (52%), and low indocyanine green elimination rate constant (KICG) (44%).

    Findings:

    • Thyroid hormone levels (T3 and T4) were lower in patients with abnormal lactic dehydrogenase (LDH), cholesterol, cholinesterase (ChE), and indocyanine green elimination rate constant (KICG).

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  • Patients with abnormal KICG exhibited a significantly higher cardio-thoracic ratio (CTR), indicative of potential pericardial effusion.
  • Liver biopsies revealed normal liver histology in most cases, with one showing mild monocyte infiltration.

    • Implications:

    • Thyroid hormone deficiency can adversely affect specific markers of liver function and cardiac status.
    • Hormone replacement therapy effectively reverses these hepatic and cardiac abnormalities associated with hypothyroidism.
    • These findings underscore the systemic impact of thyroid hormone deficiency and the importance of timely treatment.