[Prenatal action of tetracycline hydrochloride on lymph node development in the rat]

Histological and morphological methods were used to study the ante- and postnatal development of tracheobronchial and mesenterial nodes of white rats exposed to tetracycline in the preimplantation period (days 1-6 of the embryogenesis), during placentation and early organogenesis (days 8-13), and in the late organogenesis (days 14-19). Administration of tetracycline on days 1-6 and 8-13 of the embryogenesis disturbs the formation of the morphofunctional structures of the node, inhibits the lympho- and plasmocytopoiesis associated with a dramatic increase in the number of granulocytes and mast cells. Exposure to the antibiotic on days 14-19 of the embryo-genesis does not impair the formation of the lymph nodes but leads to an increase in them of the number of lymphocytes, plasmocytes, macrophages, eosinophilic granulocytes and mast cells.