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Related Experiment Videos

[Non-steroid antirheumatic agents. Criteria for a rational selection].

H Rechziegler

    Fortschritte Der Medizin
    |May 3, 1984
    PubMed
    Summary

    Choosing the right nonsteroidal anti-inflammatory drug (NSAID) is challenging due to the growing number of options. Physicians should consider key clinical parameters for rational NSAID selection and treatment.

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    Medizinische Klinik (Munich, Germany : 1983)·1990
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    [Interactions of non-steroidal antirheumatic drugs with oral antidiabetic agents: acemetacin--glibenclamide].

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    Acemetacin in the treatment of rheumatic diseases: an open, multi-centre trial.

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    [Multicentre long-term study with acemetacin (author's transl)].

    Arzneimittel-Forschung·1980

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Drug Development

    Context:

    • Increasing number of nonsteroidal anti-inflammatory drugs (NSAIDs) complicates physician decision-making.
    • Need for a rational approach to prescribing NSAIDs based on clinical evidence.

    Purpose:

    • To outline key pharmacological and tolerance parameters for selecting NSAIDs.
    • To guide physicians in making evidence-based NSAID treatment choices.

    Summary:

    • Evaluates NSAIDs based on anti-inflammatory strength, corticosteroid sparing, protein binding, and tissue drug levels.
    • Assesses NSAID tolerance by considering prostaglandin synthesis inhibition, gastrointestinal blood loss, half-life, renal elimination, drug interactions, and DNA effects.
    • Recommends prioritizing NSAIDs with available published data on these critical parameters.

    Impact:

    • Facilitates rational NSAID selection, improving therapeutic efficacy and patient safety.
    • Provides a framework for evidence-based prescribing in the face of numerous NSAID options.
    • Aims to optimize treatment outcomes by guiding the choice of NSAIDs with well-documented profiles.

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