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[Non-steroid antirheumatic agents. Criteria for a rational selection]
Fortschritte Der Medizin
|May 3, 1984
Summary
Choosing the right nonsteroidal anti-inflammatory drug (NSAID) is challenging due to the growing number of options. Physicians should consider key clinical parameters for rational NSAID selection and treatment.
Area of Science:
- Pharmacology
- Clinical Medicine
- Drug Development
Context:
- Increasing number of nonsteroidal anti-inflammatory drugs (NSAIDs) complicates physician decision-making.
- Need for a rational approach to prescribing NSAIDs based on clinical evidence.
Purpose:
- To outline key pharmacological and tolerance parameters for selecting NSAIDs.
- To guide physicians in making evidence-based NSAID treatment choices.
Summary:
- Evaluates NSAIDs based on anti-inflammatory strength, corticosteroid sparing, protein binding, and tissue drug levels.
- Assesses NSAID tolerance by considering prostaglandin synthesis inhibition, gastrointestinal blood loss, half-life, renal elimination, drug interactions, and DNA effects.
- Recommends prioritizing NSAIDs with available published data on these critical parameters.
Impact:
- Facilitates rational NSAID selection, improving therapeutic efficacy and patient safety.
- Provides a framework for evidence-based prescribing in the face of numerous NSAID options.
- Aims to optimize treatment outcomes by guiding the choice of NSAIDs with well-documented profiles.