[Differences in the quality of human albumin solutions for clinical use]

The differences in quality of 18 commercially available human albumine solutions (5%, 20%) are described. 12 of 20% albumine solutions and 5 of 5% albumine of different manufactures were testet. Results for albumine (mg/dl) vary between 82-89% under the declared value of 95% of total protein contents as far as 20% solution are concerned. All solutions have the declared minimal content of potassium as sodium is concerned they distinguish each other as semi or fully elektrolyt solutions. Values for monomer albumine which are measured by Sephadex-Chromatography range between 80,2% to 92% in 20% solutions, as for the 5% albumine solutions the fraction of monomers lies between 80-91% of the declared value of total protein. The fraction of macroaggregates lies between 1-11,7% in the 20% solutions. In 25% albumine solutions the highest ratio of 22,2% of macroaggregates was found. The difference in quality of solutions even within the same manifacturer demonstrates that there will be even differences in human albumine solutions in the future. Interchange of commercially available albumine solution is not selfevident.