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Related Experiment Videos

Chlorella photosensitization. New phytophotodermatosis.

K Jitsukawa, R Suizu, A Hidano

    International Journal of Dermatology
    |May 1, 1984
    PubMed
    Summary
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    Chlorella supplements can cause skin reactions like swelling and lesions due to a photosensitizing agent. This agent, pheophorbide-a, leads to blood vessel damage in sun-exposed areas.

    Area of Science:

    • Dermatology
    • Photobiology
    • Toxicology

    Background:

    • Chlorella, a type of algae, is widely consumed as a dietary supplement.
    • Photosensitivity reactions can be triggered by various exogenous substances.
    • Understanding the dermatological effects of supplements is crucial for patient safety.

    Observation:

    • Five patients presented with swelling and erythematopurpuric lesions on sun-exposed skin.
    • All affected individuals had ingested chlorella tablets prior to symptom onset.
    • Clinical presentation suggested a phototoxic or photoallergic reaction.

    Findings:

    • Histopathological examination revealed endothelial cell swelling and thrombosis in dermal and subcutaneous blood vessels.
    • The causative agent in chlorella was identified as pheophorbide-a and its ester.

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  • Pheophorbide-a is a potent photosensitizer, explaining the observed skin lesions.

    • Implications:

    • Chlorella supplements should be used with caution, especially in individuals prone to photosensitivity.
    • Healthcare providers should consider chlorella ingestion when patients present with unexplained photodermatitis.
    • Further research into the photosensitizing properties of algal supplements is warranted.