Pharmacokinetic study of digoxin-benzamide interaction in the rat

Simultaneous oral administration of digoxin and three benzamides (Metoclopramide, Alizapride, Bromopride) to the rat, modify digoxin's pharmacokinetic parameters: peak plasma concentration, elimination phase half life and bioavailability (Bromopride, Alizapride in function with dose-level). Our conclusion, is that drug-monitoring is necessary for this drug association.