Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple cell origin of traumatically induced keloids.

P Moulton-Levy, C E Jackson, H G Levy

    Journal of the American Academy of Dermatology
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Factors associated with Noninvasive ventilation compliance in patients with ALS/MND.

    Amyotrophic lateral sclerosis & frontotemporal degeneration·2021
    Same author

    The Use of Genetic Markers in Studies of Myeloid Neoplasia.

    Leukemia & lymphoma·2016
    Same author

    Longitudinal associations between post-traumatic stress disorder and metabolic syndrome severity.

    Psychological medicine·2016
    Same author

    Adenocarcinoma of the common bile duct with resection, anastomosis of the hepatic duct to the cystic duct and cholecystogastrostomy.

    American journal of surgery·2010
    Same author

    ACUTE INTESTINAL OBSTRUCTION DUE TO PREGNANCY IN A BICORNUATE UTERUS.

    British medical journal·2010
    Same author

    Three Cases of Gastric Carcinoma Presenting Unusual Features.

    British medical journal·2010
    Same journal

    Hypoactive Sexual Desire Disorder in Menopausal Women: Dermatologic Implications of Antiandrogen and Testosterone Therapy.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Incise parallel, section perpendicular to the dermatoglyphs for diagnosis of acral melanocytic lesions-A comment on Thakker et al.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Response to Xue et al, "Defining super-responders is not the same as predicting rituximab response in pemphigus".

    Journal of the American Academy of Dermatology·2026
    Same journal

    Comment on Nie et al. (2026) 'Suicidality Reports in Acne Patients Treated with Isotretinoin and Concomitant Antidepressants: A Descriptive Analysis of FDA Adverse Event Reporting System Data'.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Defining super-responders is not the same as predicting rituximab response in pemphigus.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Eosinophilic fasciitis induced by checkpoint inhibitors: a retrospective multicenter case-series, comparison with eosinophilic fasciitis unrelated to checkpoint inhibition and literature review.

    Journal of the American Academy of Dermatology·2026
    See all related articles

    Keloids, which are abnormal scars, do not grow from a single cell. Studies of glucose-6-phosphate dehydrogenase (G6PD) in keloid tissues show they originate from multiple cells, unlike most tumors.

    Area of Science:

    • Genetics
    • Dermatology
    • Oncology

    Background:

    • Keloids are benign fibroproliferative tumors arising from dermal injury.
    • The cellular origin of keloids remains incompletely understood, with theories ranging from clonal expansion to polyclonal origins.

    Purpose of the Study:

    • To investigate the cellular origin of keloids using glucose-6-phosphate dehydrogenase (G6PD) enzyme analysis.
    • To determine if keloid development involves clonal expansion or a multicellular origin.

    Main Methods:

    • Analysis of glucose-6-phosphate dehydrogenase (G6PD) enzyme variants (B and A) in keloid tissue samples.
    • Comparison of G6PD enzyme proportions in keloids versus normal tissue from patients heterozygous for the X-linked G6PD locus.

    Main Results:

    Related Experiment Videos

    • Both G6PD B and A enzyme variants were detected in the studied keloids.
    • The proportions of G6PD B and A enzymes in keloids were similar to those found in normal tissues.

    Conclusions:

    • Keloids exhibit a multicellular origin, indicating they arise from a population of cells rather than a single progenitor.
    • The findings suggest that keloid formation is a non-neoplastic, polyclonal process, distinguishing them from most neoplasms which arise clonally.