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Clinicopathologic correlations in leukemia cutis.

W P Su, S A Buechner, C Y Li

Journal of the American Academy of Dermatology

|July 1, 1984

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Leukemia cutis, a skin manifestation of leukemia, presents with diverse lesions across all leukemia types. Skin biopsy aids diagnosis, but its presence indicates a poor prognosis.

Area of Science:

Dermatology
Hematology
Oncology

Background:

Leukemia cutis represents leukemic cell infiltration of the skin.
It can manifest before, during, or after systemic leukemia diagnosis.

Purpose of the Study:

To analyze the clinicopathologic features of leukemia cutis.
To correlate skin manifestations with specific leukemia subtypes.
To evaluate the diagnostic and prognostic significance of leukemia cutis.

Main Methods:

Clinicopathologic review of 42 leukemia cutis cases.
Categorization based on leukemia subtype: acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute granulocytic leukemia (AGL), chronic granulocytic leukemia (CGL), acute monocytic leukemia (AML), and acute myelomonocytic leukemia (AMML).

Related Experiment Videos

Documentation of clinical presentations and specific lesion types.

Main Results:

Diverse cutaneous lesions (papules, macules, plaques, nodules, ecchymoses, purpura, ulcers) observed in all leukemia types.
Gingival hypertrophy noted exclusively in AML/AMML.
Erythroderma and bullous lesions seen only in CLL.
Cutaneous lesions can precede systemic diagnosis.

Conclusions:

Leukemia cutis is a skin dissemination of systemic leukemia.
Skin biopsy is a valuable diagnostic tool for leukemia.
The presence of leukemia cutis is associated with a significantly poor prognosis.