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Amiodarone-induced intra-His block.

E E Kennedy, W P Batsford

Journal of the American College of Cardiology

|July 1, 1984

Summary

This summary is machine-generated.

Amiodarone can cause heart block in the distal conduction system, even without prior heart disease. This effect mimics atrioventricular nodal block, highlighting a potential risk of this antiarrhythmic drug.

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Area of Science:

Cardiology
Electrophysiology
Pharmacology

Background:

Refractory ventricular arrhythmias require effective treatment.
Amiodarone is a commonly used antiarrhythmic medication.
Conduction system abnormalities can complicate arrhythmia management.

Observation:

Two patients with refractory ventricular arrhythmias were treated with amiodarone.
Electrophysiologic testing was performed before and during amiodarone therapy.
Patients had varying degrees of pre-existing conduction system disease.

Findings:

Amiodarone induced significant HV interval prolongation in both patients.
Second-degree intra-His Wenckebach block was observed during amiodarone therapy.
No changes in QRS duration were noted during atrial pacing at longer cycle lengths.

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Implications:

Amiodarone can induce distal conduction system block.
This block can occur even in patients without pre-existing conduction disease.
The findings suggest amiodarone's potential to mimic atrioventricular nodal block.