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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
Clinically unrecognized ventricular dysfunction in young diabetic patients
Journal of the American College of Cardiology
|August 1, 1984
Summary
Diabetic patients often exhibit subclinical left ventricular dysfunction during exercise, indicated by a reduced ejection fraction. This dysfunction in diabetes is not linked to common risk factors, suggesting other underlying causes.
Area of Science:
- Cardiology
- Diabetology
- Nuclear Medicine
Background:
- Diabetes mellitus is associated with cardiovascular complications.
- Left ventricular (LV) function is crucial for cardiac health.
- Subclinical cardiac dysfunction may precede overt disease in diabetic patients.
Purpose of the Study:
- To assess resting and exercise left ventricular function in diabetic patients compared to healthy controls.
- To identify potential correlations between LV dysfunction and diabetic complications or risk factors.
Main Methods:
- Gated radionuclide angiography was used to measure ejection fraction at rest and during exercise.
- Twenty diabetic patients (aged 21-44, mostly insulin-dependent) and 18 healthy controls were studied.
- Exercise involved supine bicycle ergometry.
Main Results:
- Diabetic patients had a normal resting ejection fraction but showed a significant decrease during exercise (67.7% vs. 77.1% in controls, p<0.01).
- Seven out of 20 diabetic patients exhibited decreased ejection fraction with exercise, unlike controls (1/18).
- LV dysfunction did not correlate with age, diabetes duration, smoking, retinopathy, or exercise parameters.
Conclusions:
- Approximately one-third of diabetic patients demonstrate subclinical left ventricular dysfunction during exercise.
- This dysfunction appears independent of traditional atherosclerosis risk factors and diabetic complications.
- The etiology remains unclear, possibly involving undiagnosed coronary artery disease or primary myocardial disease.
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