Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinically unrecognized ventricular dysfunction in young diabetic patients.

R R Mildenberger, B Bar-Shlomo, M N Druck

    Journal of the American College of Cardiology
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Extensive migration of injected free liquid silicone for breast augmentation with related major complications.

    BJR case reports·2018
    Same author

    The "safe" triangle, contrast material, and particulate steroids in lumbar transforaminal injections: What are the right things to do?

    Clinical radiology·2012
    Same author

    Current management of congestive heart failure.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Pathophysiology of cardiac emergencies.

    Canadian family physician Medecin de famille canadien·2010
    Same author

    Management of cardiac arrhythmias.

    Canadian family physician Medecin de famille canadien·2010
    Same author

    Weight in diabetes.

    Canadian family physician Medecin de famille canadien·2010

    Diabetic patients often exhibit subclinical left ventricular dysfunction during exercise, indicated by a reduced ejection fraction. This dysfunction in diabetes is not linked to common risk factors, suggesting other underlying causes.

    Area of Science:

    • Cardiology
    • Diabetology
    • Nuclear Medicine

    Background:

    • Diabetes mellitus is associated with cardiovascular complications.
    • Left ventricular (LV) function is crucial for cardiac health.
    • Subclinical cardiac dysfunction may precede overt disease in diabetic patients.

    Purpose of the Study:

    • To assess resting and exercise left ventricular function in diabetic patients compared to healthy controls.
    • To identify potential correlations between LV dysfunction and diabetic complications or risk factors.

    Main Methods:

    • Gated radionuclide angiography was used to measure ejection fraction at rest and during exercise.
    • Twenty diabetic patients (aged 21-44, mostly insulin-dependent) and 18 healthy controls were studied.
    • Exercise involved supine bicycle ergometry.

    Related Experiment Videos

    Main Results:

    • Diabetic patients had a normal resting ejection fraction but showed a significant decrease during exercise (67.7% vs. 77.1% in controls, p<0.01).
    • Seven out of 20 diabetic patients exhibited decreased ejection fraction with exercise, unlike controls (1/18).
    • LV dysfunction did not correlate with age, diabetes duration, smoking, retinopathy, or exercise parameters.

    Conclusions:

    • Approximately one-third of diabetic patients demonstrate subclinical left ventricular dysfunction during exercise.
    • This dysfunction appears independent of traditional atherosclerosis risk factors and diabetic complications.
    • The etiology remains unclear, possibly involving undiagnosed coronary artery disease or primary myocardial disease.