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Related Experiment Videos

Experimental systemic dermatophytosis.

J Van Cutsem, P A Janssen

    The Journal of Investigative Dermatology
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Dermatophyte infections in guinea pigs can spread to internal organs after intravenous inoculation, causing generalized disease. This deep-seated infection may lead to recurrent ringworm, highlighting the need for effective treatment strategies.

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    Area of Science:

    • Mycology
    • Veterinary Dermatology
    • Infectious Diseases

    Background:

    • Dermatophytes are fungi causing superficial skin infections.
    • Understanding dermatophyte dissemination is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the infectivity and dissemination of dermatophyte strains in animal models.
    • To evaluate the course of dermatophytosis following different inoculation routes.

    Main Methods:

    • Cutaneous and intravenous inoculation of 27 dermatophyte strains in guinea pigs.
    • Intravenous inoculation of a specific strain (T. mentagrophytes B32663) in multiple animal species.
    • Reisolation of fungi from skin and internal organs; histopathological examination of lung tissue.

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    Main Results:

    • Cutaneous inoculation caused ringworm with specific zoophilic and human strains.
    • Intravenous inoculation led to systemic fungal presence in skin, lungs, liver, and kidneys, with or without visible lesions.
    • Generalized dermatophytosis affecting skin and internal organs occurred with some strains.
    • T. mentagrophytes B32663 caused systemic infection in guinea pigs, rabbits, rats, mice, and chickens, with varied organ involvement.
    • Infection was not self-limiting, suggesting deep-seated lesions contribute to recurrence.

    Conclusions:

    • Intravenous inoculation of dermatophytes can result in systemic infections beyond the skin.
    • The route of administration significantly influences the manifestation and dissemination of dermatophytosis.
    • Deep-seated fungal lesions may underlie the recrudescent nature of dermatophyte infections.