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Increased conjugated dopamine in plasma after exercise training.

A A Bove, J D Dewey, G M Tyce

    The Journal of Laboratory and Clinical Medicine
    |July 1, 1984
    PubMed
    Summary
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    Endurance exercise training in dogs lowers plasma norepinephrine and epinephrine. Exercise training also significantly increases plasma conjugated dopamine, suggesting a metabolic shift in catecholamines.

    Area of Science:

    • Cardiovascular Physiology
    • Exercise Physiology
    • Neuroendocrinology

    Background:

    • Plasma catecholamines, including norepinephrine and epinephrine, play crucial roles in cardiovascular regulation.
    • The metabolic adaptations of catecholamines in response to endurance exercise are not fully understood.
    • Understanding these changes is vital for comprehending the physiological benefits of exercise training.

    Purpose of the Study:

    • To investigate the impact of a structured endurance exercise program on plasma catecholamine levels in dogs.
    • To determine if exercise training alters resting and exercise-induced catecholamine concentrations.
    • To examine the relationship between exercise training and conjugated dopamine levels.

    Main Methods:

    • Eight dogs underwent 8 weeks of treadmill running (trained group, T).

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  • Six dogs served as a sedentary control group (non-trained group, NT).
  • Plasma catecholamine levels (norepinephrine, epinephrine, conjugated dopamine) were measured at rest and during exercise. Cardiovascular parameters were also assessed.

    • Main Results:

    • Trained dogs showed reduced heart rate response to stress tests.
    • Resting and exercise plasma norepinephrine and epinephrine levels were lower in trained dogs.
    • Plasma conjugated dopamine levels markedly increased in trained dogs at rest.
    • No significant changes in resting coronary flow, coronary arteriovenous oxygen, or myocardial oxygen consumption were observed.

    Conclusions:

    • Exercise training reduces plasma levels of active catecholamines, norepinephrine and epinephrine.
    • Endurance exercise training induces a significant increase in plasma conjugated dopamine in dogs.
    • These findings suggest that exercise training shifts catecholamine metabolism towards conjugated dopamine, reducing circulating active catecholamines while maintaining a reserve pool.